While preparing for work on another problem it was decided to employ the histamine test of gastric secretory function as a part of the study. A search for data concerning the use of the test in children yielded only a few references and revealed the desirability of work on the subject. Literature on the histamine test in the adult is copious. According to Lee,1 the test resulted as a development of work by Dale and Richards in 1918 and of Popielski in 1920. Bockus and Bank2 accredit Carnot, Koskowski and Liebert with the first observation regarding the effect of histamine on the human stomach. Since its introduction as a test of gastric secretory function, the histamine test has enjoyed great vogue. The enthusiasm with which the test was heralded and accepted is, no doubt, an expression of a widespread recognition of inaccuracy and inadequacy of the gastric function
SIEMSEN WJ. HISTAMINE TEST OF GASTRIC SECRETIONWITH PARTICULAR REFERENCE TO ITS PRACTICABILITY IN CHILDHOOD; A PRELIMINARY COMMUNICATION. Am J Dis Child. 1932;44(5):1013–1025. doi:10.1001/archpedi.1932.01950120095007
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