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December 1932

IMMUNIZATION AGAINST DIPHTHERIA WITH TOXOID: WITH SPECIAL REFERENCE TO THE TIME INTERVAL AND SIZE OF INJECTIONS

Am J Dis Child. 1932;44(6):1249-1258. doi:10.1001/archpedi.1932.01950130099007
Abstract

It is not my purpose to discuss the relative merits of toxin-antitoxin and toxoid. This phase has been thoroughly investigated by Ramon and Helie,1 Zingher,2 Bloomberg and Fleming,3 Mozer,4 Harrison5 and more recently in this clinic by Weinfeld and Cooperstock6 and other observers (table 1). The conclusions arrived at by these workers are that toxoid is superior to toxin-antitoxin for the following reasons: 1. Sensitization to horse serum is eliminated. 2. The solution is more stable. 3. Fewer injections are needed. 4. The immunizing power is greater and more rapid.

The original technic as described by Ramon and Helie1 is as follows:

"An initial dose of 0.5 cc. of anatoxin is injected subcutaneously; three weeks later 1.0 cc. is injected, and in many cases if not all, a third injection of from 1.0 cc. to 1.5 cc. is given fifteen days after the

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