The problem of urinary antisepsis is an old one. There has been for years an effort to provide a satisfactory urinary antiseptic for the infectious conditions involving the genito-urinary system. From time to time new preparations are suggested. However, after clinical and experimental studies with these so-called antiseptics, it is conclusive from reported results that an entirely suitable drug has not yet been presented. After a "heyday" of varying length the popularity of each has waned when it has been found to be lacking in one or more of the qualifications for ideal urinary antiseptics suggested by Hinman1 and later by Davis.2 The ideal urinary antiseptic should be chemically stable and nontoxic in therapeutic doses. It should be eliminated in high percentage by the kidneys, should exert antiseptic action in high dilution in urines of varying reactions and should, of course, be non-irritating to the genito-urinary tract. Leonard
GILLESPIE JB. EXPERIMENTS ON THE ANTIBACTERIAL PROPERTIES OF PYRIDIUM AND SERENIUM. Am J Dis Child. 1933;45(2):254–270. doi:https://doi.org/10.1001/archpedi.1933.01950150027002
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