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May 1933

INTERPLAY OF PIESTIC FACTORS AT BIRTHWITH A CONSIDERATION OF THEIR PHYSIOLOGIC AND CLINICAL SIGNIFICANCE

Am J Dis Child. 1933;45(5):1007-1021. doi:10.1001/archpedi.1933.01950180079006
Abstract

In reviewing the factors concerned with the function of the ductus arteriosus, a hypothesis of the interplay of piestic factors at birth has been developed which coordinates the data of all the previous antagonistic theories dealing with this process. The major tenets have been held and tested over a period of two years. Recently, while reviewing the bibliographic references to the subject, my associates and I came across the theory of "reversal" of the respiratory center as developed by Schmidt.1 This concept fits so perfectly into our argument that we believe our hypothesis supported in every detail and hence venture this initial report, since we think that the interpretation of asphyxia neonatorum and cerebral hemorrhage in the new-born is materially advanced.

In presenting our experimental and observational data, we shall not follow the typical form of organization, but shall introduce the materials at the points where they fit most logically

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