In the course of some observations made five years ago on children recovering from severe bouts of vomiting, I noted a failure of elevation of the respiratory quotient following the intravenous administration of glucose. Because such states involve so many variables, viz., an accompanying infection, emotion, alteration in the acid-base balance or similar influences, the present studies were undertaken in order to analyze further the factors affecting the utilization of intravenously administered glucose.
Lehmann1 in 1874 and Hofmeister2 in 1890 described "diabetes" due in the first instance to either arsenic poisoning or starvation and in the second to starvation. The similarity of the states induced by arsenic poisoning and by starvation naturally suggested that the site of the metabolic flaw was in the liver. This idea was further developed by the work of Barrenschen3 in 1914 and by that of Nagasuye4 in 1925. The reproduction of