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March 1934

DIURESIS PRODUCED BY INJECTION OF DEXTROSE: ITS EFFECT ON NITROGEN BALANCE AND ON METABOLISM OF FIXED ACIDS AND BASES IN NORMAL INFANTS

Author Affiliations

NEW YORK
From the Department of Pediatrics, Cornell University Medical College, and the New York Nursery and Child's Hospital.

Am J Dis Child. 1934;47(3):513-520. doi:10.1001/archpedi.1934.01960100039004
Abstract

Induction of diuresis by the intravenous administration of hypertonic solutions of dextrose is a well recognized therapeutic measure for the relief of many forms of intoxication, especially for the form frequently accompanying infantile diarrhea. The effects on the circulation and the changes in the blood during and immediately following induction of diuresis have been amply studied in normal animals, but reports of prolonged observations following this procedure are not available in the literature.

It was possible to obtain data on two normal infants to whom hypertonic solutions of dextrose had been administered intravenously and to follow the metabolism of fixed acids and bases in these subjects for periods of nine days following the initial diuresis. The main objects of this paper are to present data on:

  1. The immediate effect of dextrose diuresis on the body content of fixed acids and bases in normal infants.

  2. The time interval necessary

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