Pituitary dysfunction, usually of the hyposecretion type, occurring in children before or during adolescence, is not a rarity. The result of this hyposecretion, however, is, in the majority of cases, obesity with genital and secondary sexual retardation. I shall present a case of hyposecretion of the anterior lobe resulting in emaciation with marked genital and secondary sexual retardation. Lorain,1 in 1871, published the first exact clinical description of this type of infantilism, but he did not associate the condition with a lesion of the pituitary gland. De Sanctis, in 1905, first associated this form of infantilism with an abnormal endocrinologic condition. In 1908, E. Levi published a case in which roentgenograms showed an enlarged and deformed sella turcica, probably due to the presence of a pituitary tumor. H. Cushing reported a case in 1912. Blair Bell, in 1919, and Parkes Weber, in 1921, also published a few cases in
DUNLAP JE. PREADOLESCENT ANEOPLASTIC DYSPITUITARISM OF LORAIN TYPE. Am J Dis Child. 1934;47(3):578–585. doi:10.1001/archpedi.1934.01960100104012
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