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April 1934

INTRANUCLEAR INCLUSIONS: INCIDENCE AND POSSIBLE SIGNIFICANCE IN WHOOPING COUGH AND IN A VARIETY OF OTHER CONDITIONS

Am J Dis Child. 1934;47(4):771-779. doi:10.1001/archpedi.1934.01960110054005
Abstract

Whooping cough, measles and epidemic influenza are frequently complicated by a characteristic type of pneumonia which MacCallum1 called interstitial bronchopneumonia, because the essential feature distinguishing it from ordinary lobular pneumonia or bronchopneumonia is an infiltration of the bronchial and alveolar walls by mononuclear cells. In addition to the interstitial cellular infiltration a polynuclear exudate is usually found in the central bronchiole and some of the surrounding alveoli (fig. 1). Various types of bacteria have been regarded as the cause of interstitial bronchopneumonia by different authors. In a study of pneumonia in rabbits caused by vaccine virus, Muckenfuss and McCordock2 described infiltration of the interstitial pulmonary tissue by mononuclear cells. There has also been reproduced in animals the complete picture of interstitial bronchopneumonia as seen in man, by injecting vaccine virus with a suspension of various types of bacteria.3 This work suggests that interstitial bronchopneumonia results from the

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