It is generally agreed that the most satisfactory method of active diphtheria immunization is the subcutaneous administration of diphtheria toxoid (diphtheria anatoxin-Ramon). The results of vaccination with this material have been very satisfactory. In 1929 the selection of all persons showing a positive reaction to the Schick test and their immunization by the use of diphtheria toxoid were established as a routine procedure in the St. Vincent's Infant Hospital. Vaccinations were done regardless of age as soon as a positive reaction was obtained, and the resultant immunity was measured by follow-up Schick tests at intervals of two weeks after the final injection. A preliminary report of the results obtained was published in 1931.1 In 98 of this group of 100 infants, the reaction to the Schick test rapidly became negative and in 2 it remained persistently positive. Since then the total series has increased to 304; in 214 of
GREENGARD J. IMMUNITY PRODUCED BY DIPHTHERIA TOXOID. Am J Dis Child. 1934;47(4):799–807. doi:10.1001/archpedi.1934.01960110082008
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