Werlhof described purpura haemorrhagica in 1735, while Otto,1 in 1803, in an article called "An Account of an Hemorrhagic Disposition in Certain Families" first recorded a description of hemophilia. Since then many articles have been published to explain the differentiation of and the relationship between these two conditions, as well as to describe many atypical cases of hemorrhagic disease which cannot be grouped with either of these conditions. In 1916 Hess2 made the statement that "it is becoming increasingly evident that the group termed 'the hemorrhagic diseases' includes a large number of abnormal conditions and that, at the present time, it is a fruitless task to attempt to unravel the various entities embraced by the clinical conditions which are assembled under this general head." This unraveling process has been carried on since and is still progressing.
Hemophilia is easily diagnosed, if the condition seen is in a male
WEEKS E. FAMILIAL BLEEDING: REPORT OF TWO CASES. Am J Dis Child. 1934;47(6):1318–1322. doi:10.1001/archpedi.1934.01960130142011
Monkeypox Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.