The treatment of syphilis in children has been so varied that we had hoped that a standardized and simplified method could be used in all cases of congenital syphilis. Arsenicals in the form of neoarsphenamine and sulpharsphenamine, mercurials in different forms and bismuth preparations have been the outstanding medications in all clinics. These drugs are given intravenously or intramuscularly. The use of oral medication has been discarded for many years. However, as there are many discomforts attending the use of hypodermic injection, there is no reason why an attempt should not be made to return to oral administration if it produces results similar to those received from intramuscular or intravenous injections.
The drug employed in our cases was a preparation used by Levaditi and Ehrlich. It is known under the names acetarsone, stovarsol and spirocid. Levaditi and Navarro-Martin1 were first able to demonstrate its effectiveness when used by mouth
JOSEPH YAMPOLSKY, DONALD F. CATHCART, INMAN SMITH. ACETARSONE IN THE TREATMENT OF SYPHILIS IN NEGRO CHILDREN. Am J Dis Child. 1934;48(1):81–100. doi:10.1001/archpedi.1934.01960140090009