In spite of the advances made in the prophylaxis of rickets in the full-term infant rickets is still a threat to the premature infant who survives the neonatal period.
Various authors from time to time have stressed one or all of the following etiologic factors for the prevalence and severity of rickets in the premature infant: (1) the relatively rapid growth of the premature as compared with the normal full-term infant; (2) the tendency of the premature infant to anemia; (3) the fact that its size and frailty necessitate its remaining indoors throughout the early weeks and months, often away from sunlight, and (4) a deficient store of calcium at birth. Abt1 said: "In spite of everything you do with prematures, if they are viable, they are likely to develop rickets," and, again, "All premature infants have a marked predisposition to rickets.... they grow rapidly, and rapidly growing babies
DAVIDSON LT, MERRITT KK. VIOSTEROL IN THE PROPHYLAXIS OF RICKETS IN PREMATURE INFANTS: CLINICAL, CHEMICAL AND ROENTGENOLOGIC OBSERVATIONS. Am J Dis Child. 1934;48(2):281–308. doi:10.1001/archpedi.1934.01960150040004
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