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December 1934

TYPHOID PARATYPHOID THERAPY IN IDIOPATHIC EPILEPSY: A CLINICAL AND EXPERIMENTAL STUDY

Am J Dis Child. 1934;48(6):1201-1208. doi:10.1001/archpedi.1934.01960190021003
Abstract

Of the diseases in which the etiology, pathogenesis and treatment are on an infirm and unscientific foundation, epilepsy stands preeminent. In the past a great deal has been written on the subject, and many interesting observations have been recorded by capable clinicians and neurologists; yet despite this voluminous literature, and despite a vast amount of experimental work that has been done, the conception of this disease has not been materially enhanced in the past fifty years. The etiology and the pathogenesis of this disease are as obscure today as they were a century ago.

REVIEW OF LITERATURE  In 1881, William Gowers1 expressed the view that epilepsy is a disease of the gray matter and has no uniform seat, and that the cause of the convulsive seizure may be a subtle disturbance in the cellular physiology of the brain rather than a gross lesion. The conception of this disease today

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