The more important features to be presented here are:
There is definite proof that the retarded osseous development in congenital sporadic cretinism has its origin in utero.
There is an apparent relationship of this osseous retardation to a disturbance of the thyroid gland in the fetus.
Two additional cases of cretinism in one of differently sexed fraternal twins are reported, with roentgen demonstration of the occurrence of osseous retardation in utero in one case.
The probable deductions that may be made in the physiology are discussed.
A review of the American literature shows the paucity of reports on sporadic cretinism in twins. Two cases were reported by Gordon1 in a review of a series of three hundred and forty cases of myxedema in childhood in North America. In his series he cited one case reported by Charles Herrman,2 in male twins, 6½ years of
DORFF GB. SPORADIC CRETINISM IN ONE OF TWINS: REPORT OF CASES WITH ROENTGEN DEMONSTRATION OF OSSEOUS CHANGES THAT OCCURRED IN UTERO. Am J Dis Child. 1934;48(6):1316–1325. doi:10.1001/archpedi.1934.01960190136015
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: