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Case Reports
December 1934

SPORADIC CRETINISM IN ONE OF TWINS: REPORT OF CASES WITH ROENTGEN DEMONSTRATION OF OSSEOUS CHANGES THAT OCCURRED IN UTERO

Author Affiliations

BROOKLYN
From the endocrine clinics of the Department of Pediatrics of New York University and Medical College and of Bellevue Hospital, Dr. Charles Hendee Smith, Director of Pediatrics.

Am J Dis Child. 1934;48(6):1316-1325. doi:10.1001/archpedi.1934.01960190136015
Abstract

The more important features to be presented here are:

  1. There is definite proof that the retarded osseous development in congenital sporadic cretinism has its origin in utero.

  2. There is an apparent relationship of this osseous retardation to a disturbance of the thyroid gland in the fetus.

  3. Two additional cases of cretinism in one of differently sexed fraternal twins are reported, with roentgen demonstration of the occurrence of osseous retardation in utero in one case.

  4. The probable deductions that may be made in the physiology are discussed.

A review of the American literature shows the paucity of reports on sporadic cretinism in twins. Two cases were reported by Gordon1 in a review of a series of three hundred and forty cases of myxedema in childhood in North America. In his series he cited one case reported by Charles Herrman,2 in male twins, 6½ years of

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