Among the chemical elements which are present in animal and vegetable life in such infinitesimal amounts as to require estimation by micromethods or ultramicromethods iodine is unique in that its essential rôle in normal animal life was the first to be recognized. In the eighty years which have passed since the first observation of Chatin1 that the incidence of goiter is in inverse relation to the iodine content of the food and water of a region, a rapidly expanding wealth of information has been accumulated as to the amount of this element available through food and drink to the inhabitants of many parts of the earth. It appears to be definitely established that the supply of iodine in the environment of persons living in regions in which enlargement of the thyroid gland is of merely sporadic occurrence is much greater than the supply in regions in which such enlargement
HOLMES AD, REMINGTON RE. IODINE CONTENT OF AMERICAN COD LIVER OIL. Am J Dis Child. 1935;49(1):94–100. doi:https://doi.org/10.1001/archpedi.1935.01970010103011
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