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February 1935

BLOOD PHOSPHORUS DURING DEVELOPMENT AND HEALING OF RICKETS: NOTES ON THE LACK OF RELATIONSHIP BETWEEN THE LEVEL OF PLASMA PHOSPHORUS AND THE RACHITIC STATE

Author Affiliations

CINCINNATI
From The Children's Hospital Research Foundation and the Department of Pediatrics, College of Medicine, University of Cincinnati.

Am J Dis Child. 1935;49(2):318-326. doi:10.1001/archpedi.1935.01970020033003
Abstract

For many years after Iverson and Lenstrup1 and Howland and Kramer2 found low values for inorganic serum in rachitic children, this change in blood chemistry was regarded not only as a constant symptom but also as an etiologic factor in active rickets. However, in the last few years several investigators have concluded that certain clinical as well as experimental observations indicate a lack of relationship between the development and cure of rickets and the concentration of inorganic phosphorus in the blood. In 1922 Hess and Unger3 stated that normal values for inorganic blood phosphorus are occasionally found in rickets. In an experimental study in rats, Hess, Weinstock, Rivkin and Gross4 pointed out:

Rickets may be associated with normal concentrations of inorganic phosphorus in the blood. If milk is incorporated in a standard rickets-producing ration and small amounts of irradiated ergosterol are added, the inorganic phosphorus is

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