From previous studies1 it was concluded that there is a depression of the local skin reaction to tuberculin during the acute stage of certain infections. Observations were continued so that statistical evaluation could be made.
In the first article,1a in 1928 reference was made to the medical literature. Since then a number of reports on the nonspecific effect of conditions other than tuberculosis on the reaction to tuberculin have appeared in the literature. Many of these record such a small number of observations and are so inconclusive that they hardly warrant quotation. Debré2 concluded from his study of 229 children that the anergic effect of measles on the reaction to tuberculin was greater the more marked the rash and the higher the temperature. Lereboullet and Baize3 observed 16 persons who gave a positive skin reaction to tuberculin. During measles 14 showed a depression of skin sensitivity
MITCHELL AG, NELSON WE, LEBLANC TJ, BROWN EW. STUDIES IN IMMUNITY: V. EFFECT OF ACUTE DISEASES ON THE REACTION OF THE SKIN TO TUBERCULIN. Am J Dis Child. 1935;49(3):695–702. doi:10.1001/archpedi.1935.01970030141012
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