The beneficial effects of the ketogenic diet high in fats in a goodly percentage of the cases of marked epilepsy in children treated by this means prompted McQuarrie, Husted and Bloor1 to investigate the lipoids of the blood plasma in epilepsy. Prior to this work, observations had been made on the cholesterol content of the blood in epilepsy, but no uniformity of results was established. Some investigators found hypocholesteremia, and some, hypercholesteremia, while others were unable to demonstrate any change in the cholesterol content of the blood. Until the report of McQuarrie and his associates, little or no knowledge was obtainable concerning the other blood lipoids in epilepsy. These workers demonstrated clearly that the phospholipoid-cholesterol ratio in the blood of an epileptic patient during, or just preceding or following, an attack is higher than at any other time, thus establishing definitely a relationship of the blood lipoids to status
COWIE DM, MAGEE MC. STUDIES ON LIPOIDS AND LIPOID DISEASES: IV. THE LIPOID CONTENT OF TISSUES IN CASES OF STATUS EPILEPTICUS, TOXIC ENCEPHALOPATHY AND CHRONIC LEPTOMENINGITIS. Am J Dis Child. 1935;49(4):884–893. doi:https://doi.org/10.1001/archpedi.1935.01970040052006
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