Since the time of Jenner (1791) it has been recognized that the use of a virus attenuated by passage through animals of another species can confer a high degree of immunity. Nevertheless, in the years since then the technical procedure employed in the inoculation of vaccinia virus as a prophylactic measure against the allied, more severe disease smallpox has undergone few essential modifications. The method employed at present for immunization against smallpox is certainly not completely satisfactory. The local reaction is often quite marked and may result in a rather unsightly scar; at times secondary pox appears at distant sites. The frequent concomitant systemic reaction is also of importance, especially in young infants, in whom the high temperature and general malaise often result in a general lowering of resistance and an increased susceptibility to infection of the respiratory and intestinal tracts. The occurrence of erysipelas about the local lesion is
FRISCH IA. VIRUS—ANTIVIRUS MIXTURES IN SMALLPOX VACCINATION. Am J Dis Child. 1935;49(4):894–899. doi:10.1001/archpedi.1935.01970040062007
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