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May 1935

PHOSPHATASE STUDIES ON BIOPSY TISSUE IN PROGRESSIVE MYOSITIS OSSIFICANS: WITH A REPORT OF A CASE

Author Affiliations

NASHVILLE, TENN.
From the Departments of Biochemistry and Surgery, Vanderbilt University School of Medicine.

Am J Dis Child. 1935;49(5):1219-1221. doi:10.1001/archpedi.1935.01970050117012
Abstract

The evidence supporting Robison's1 theory of the rôle of phosphatase in the formation of bone is strong in spite of its being largely circumstantial. The observations reported in this case offer further indirect evidence in support of the concept that phosphatase is intimately associated with the process of ossification. We present here a preliminary study of a number of sections of tissue removed for biopsy from a white girl 16 years of age who for nine years had had proved myositis ossificans progressiva and who during this period had been under the observation of one of us (G. K. C.).

REPORT OF CASE  During the course of this study the patient suffered two acute flare-ups of the process, the first in the right biceps muscle and the second in the left pectoralis major muscle. The first biopsy was made on the right biceps muscle about six weeks after the

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