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June 1935

PROGNOSIS OF THE NEPHROTIC SYNDROME IN CHILDREN: A CLINICAL STUDY

Author Affiliations

TUCSON, ARIZ.
From the Harriet Lane Home for Invalid Children of the Johns Hopkins Hospital and the Department of Pediatrics, Johns Hopkins University, Baltimore.

Am J Dis Child. 1935;49(6):1487-1502. doi:10.1001/archpedi.1935.01970060091008
Abstract

Nephrosis, as a pathologic concept, was first described in 1905 when Muller suggested the term to designate purely degenerative conditions of the kidney. In 1906 Munk pointed out the clinical significance of lipoid bodies in the urinary sediment, and later he gave the name "lipoid nephrosis" to conditions in which they were found. In 1914 Volhard and Fahr accepted Muller's definition of nephrosis and used it to denote one of their three major divisions of renal disease. As such it included all types of renal disease in which at autopsy the lesions were found to be solely of degenerative type. The pathologic changes were not necessarily restricted to the tubules, but, if glomerular changes were present, they were of a noninflammatory nature. At this stage in the evolution of the term, therefore, "nephrosis" was used to describe a group of conditions covering all cases of degenerative Bright's disease, from the

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