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June 1935

Zur Pathogenese, Klinik und Systematik der frühkindlichen Lungenentzündungen.

Am J Dis Child. 1935;49(6):1685. doi:10.1001/archpedi.1935.01970060289025

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From a study of a large number of cases checked by roentgen findings and observations at autopsy, Wiskott presents an extremely interesting classification and interpretation of the pneumonias of infancy and early childhood. He believes that the type of reaction to infection, judged by the clinical course, roentgen findings and observations at autopsy, is characteristic of the age period rather than of the infecting organism. For instance, in infants under 4 months of age, although the organism most frequently found is a pneumococcus, one rarely sees lobar pneumonia. The reaction is usually diffuse, extending out from the hilus on both sides—a perivasobronchial type—or it may be a finely disseminated miliary pneumonia or the primary abscess-forming septic type of Finkelstein. As a background for this, he points out the greater permeability of lining cells, the lack of a localizing defense mechanism and the failure of antibody formation. This he calls the

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