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September 1935

PROPHYLACTIC USE OF PARENTS' WHOLE BLOOD IN ANTERIOR POLIOMYELITISPHILADELPHIA EPIDEMIC OF 1932

Am J Dis Child. 1935;50(3):581-595. doi:10.1001/archpedi.1935.01970090011002
Abstract

The great need for the prevention of poliomyelitis prompted this study of the effects of parents' whole blood and convalescent serum used solely as a prophylactic measure. Poliomeylitis developed in a certain number of children who received the injections. We have attempted to correlate the potency of the blood of the donors with the type of disease experienced by the children and to compare the potency of the donor's blood with that of the blood of the children when they became convalescent. Finally, we determined the immune properties of the blood of physicians and a nurse who had been in attendance on patients with poliomyelitis.

Passive immunization to anterior poliomyelitis by means of adult whole blood and serum or by means of convalescent serum is based on three main premises: 1. Other virus diseases, such as measles, can be prevented or modified by similar passive immunization. 2. Several investigators have

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