In 1932, Engle1 demonstrated that the use of an extract of the anterior lobe of the pituitary gland or of the urine of pregnant women in immature rats and monkeys caused a definite increase in the size of the testes. This was due to an increase in tubular growth and in interstitial cellular mass. However, no change in gametogenesis was noted by him in his experiment. He suggested the possible application of this phenomena to the human being.
As a result of Engle's work, Goldman and Stern2 proceeded with a study on human beings and demonstrated the effectiveness of the anterior pituitary-like gonadotropic hormone on the undescended testes of two adolescent boys. B. Schapiro3 had obtained good results in a group of males presenting hypoplastic and undescended testes by the use of a commercial gonadotropic preparation.4
Subsequently, Brosius and Schaffer5 produced spermatogenesis in a man
DORFF GB. MALDEVELOPMENT AND MALDESCENT OF THE TESTES: REPORT OF TREATMENT WITH THE ANTERIOR PITUITARY-LIKE GONADOTROPIC HORMONE FROM THE URINE OF PREGNANT WOMEN. Am J Dis Child. 1935;50(3):649–660. doi:https://doi.org/10.1001/archpedi.1935.01970090079008
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