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December 1935

SYNDROME OF DIFFUSE MUSCULAR HYPERTROPHY IN INFANTS CAUSING ATHLETIC APPEARANCE: ITS CONNECTION WITH CONGENITAL MYXEDEMA

Author Affiliations

Professor of the Faculty of Medicine of Paris and Member of the French Academy of Medicine; Member of the Staff of St. Joseph Hospital PARIS, FRANCE

Am J Dis Child. 1935;50(6):1351-1361. doi:10.1001/archpedi.1935.01970120003001
Abstract

In 1925, we had the honor of showing to the Pediatric Society of Paris1 a baby 10 months old whose appearance seemed interesting. He presented a syndrome unknown to the pediatricians at the time. Eight years later we had the opportunity of seeing another child with symptoms of the same type.

In 1934, in the American Journal of Diseases of Children, Dr. Cornelia de Lange2 published a very interesting article on "congenital hypertrophy of the muscles, extrapyramidal motor disturbances and mental deficiency."

In the present article we give a full history of our two observations of this syndrome, with photographs.

OBSERVATION 1  On Oct. 5, 1925, Claire B., aged 10 months, was admitted to the Crêche of the Hospital des Enfants Malades for treatment for stationary weight and prolapse of the rectum (fig. 1). At birth, the baby was slightly premature, weighing less than 2,000 Gm. She was

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