Studies of the substances involved in the coagulation of the blood of the new-born infant have been presented in previous communications from this department.1 In the course of further experimentation in this field we became dissatisfied with the refractometric method for the determination of fibrinogen which we had previously used. Examination was made, therefore, of the plasma of another series of infants, and the fibrin values were determined by the micro-Kjeldahl method or by weighing the dried clots. The results of this investigation are presented here.
Natural plasma was used to avoid the possible error caused by oxalate or citrate, which has been said to draw fluid from the cells and thus dilute the plasma.2 From 4 to 6 cc. of blood was drawn through the fontanel or by puncture of the internal jugular vein into an oiled and chilled syringe. The blood was immediately transferred to
CRANE MM, SANFORD HN. SUBSTANCES INVOLVED IN THE COAGULATION OF THE BLOOD OF THE NEW-BORN INFANT: IV. VARIATIONS IN THE FIBRINOGEN CONTENT IN THE NORMAL INFANT. Am J Dis Child. 1936;51(1):99–103. doi:10.1001/archpedi.1936.01970130108008
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