The experiment described in this paper was undertaken in an attempt to shed additional light on the relationship between abnormalities of the intake of minerals and of vitamin D by the mother and the mineralization of the rat fetus. Specifically, we wished to know whether: (1) mineral deficiency of the mother during gestation results in a demonstrable mineral deficiency in the fetus; (2) maternal mineral deficiency not severe enough to show osteoporosis in a roentgenogram could affect fetal mineral metabolism; (3) demineralizing effects of hypervitaminosis D, such as those observed by Harris in young rats on a diet low in calcium and phosphorus, were apparent in the offspring of rat mothers who were similarly maintained; (4) vitamin D in therapeutic doses administered to pregnant rats being maintained on a diet deficient in calcium and phosphorus would change materially the mineral content of the fetus. The effects on the developing fetus
MUNSON P, HUFF E. EFFECTS ON THE FETUS OF HYPERVITAMINOSIS D AND CALCIUM AND PHOSPHORUS DEFICIENCY DURING PREGNANCY: LESTER WARREN SONTAG, M.D. Am J Dis Child. 1936;51(2):302–310. doi:10.1001/archpedi.1936.01970140066007
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