In a previous study1 two of us found that a daily dose of 20 drops of a commercial preparation of viosterol 250 D (5,000 U.S.P. X units, revised 19342) was insufficient for the complete protection of premature infants from rickets. At the suggestion of Dr. Martha M. Eliot, of the Children's Bureau, Washington, D. C., we undertook the present study with another preparation of viosterol, the bio-assay of which had been made by the Food and Drug Administration, Department of Agriculture. The literature on the administration of viosterol to infants up to June 1933 was summarized in our earlier study,1 with the exception of a paper by Barnes, Brady and James,3 in which they compared the antirachitic effect of cod liver oil, viosterol and cod liver oil combined with viosterol. They also studied a control group of infants to whom no antirachitic therapy was given. Their
DAVIDSON LT, MERRITT KK, CHIPMAN SS. FURTHER STUDIES OF VIOSTEROL IN THE PROPHYLAXIS OF RICKETS IN PREMATURE INFANTS. Am J Dis Child. 1936;51(3):594–608. doi:10.1001/archpedi.1936.01970150098008
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