During the continuation of an epidemiologic study1 of disease of the respiratory tract in children in the winter of 1934-1935, the ferret was included as an experimental animal. The use of this animal was suggested by Smith, Andrewes and Laidlaw2 and Francis,3 who demonstrated the susceptibility of the ferret to a filtrable virus recovered from persons with influenza. From the children of the group who were ill with what was apparently epidemic influenza, we obtained five strains of an agent which was capable of producing a febrile infection of the respiratory tract in ferrets, such as was described by the aforementioned workers. This agent was not recovered from persons suffering from other diseases included in the study.
In this paper we wish to describe the clinical material and the methods used. In a subsequent section our studies on the results of the inoculation of ferrets with strains
BRIGHTMAN IJ, TRASK JD. RECOVERY OF A FILTRABLE VIRUS FROM CHILDREN WITH INFLUENZA: I. EPIDEMIOLOGIC AND CLINICAL OBSERVATIONS. Am J Dis Child. 1936;52(1):67–77. doi:10.1001/archpedi.1936.04140010076007
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