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July 1936

HYPOPHYSEAL INFANTILISM: TREATMENT WITH AN ANTERIOR HYPOPHYSEAL EXTRACT; FINAL REPORT

Author Affiliations

SANTA BARBARA, CALIF.; BERKELEY, CALIF.

Am J Dis Child. 1936;52(1):100-113. doi:10.1001/archpedi.1936.04140010109010
Abstract

In 1933 we presented a study of the effect of an extract of the anterior lobe of the hypophysis extract on six dwarfish children presumed to be suffering from hypophyseal infantilism.1 In this paper we wish to report subsequent findings in all six cases.

While the protocols herein presented begin at the end of the previous period of observation, the charts depicting the growth increment cover the entire period, of nearly five years. Reference to the original article will tend to enhance the continuity.

REPORT OF CASES  Case 1 (B. P.).—Observation.—The period of observation previously reported ended on May 1, 1933. The present period began on that date. An alkaline extract of the anterior lobe of the bovine hypophysis (extract B)2 was given five days each week intragluteally. The average daily dose was 5 cc. The period of treatment ended on Dec. 21, 1934, having extended

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