In 1933 we presented a study of the effect of an extract of the anterior lobe of the hypophysis extract on six dwarfish children presumed to be suffering from hypophyseal infantilism.1 In this paper we wish to report subsequent findings in all six cases.
While the protocols herein presented begin at the end of the previous period of observation, the charts depicting the growth increment cover the entire period, of nearly five years. Reference to the original article will tend to enhance the continuity.
REPORT OF CASES
Case 1 (B. P.).—Observation.—The period of observation previously reported ended on May 1, 1933. The present period began on that date. An alkaline extract of the anterior lobe of the bovine hypophysis (extract B)2 was given five days each week intragluteally. The average daily dose was 5 cc. The period of treatment ended on Dec. 21, 1934, having extended
SHELTON EK, CAVANAUGH LA, EVANS HM. HYPOPHYSEAL INFANTILISM: TREATMENT WITH AN ANTERIOR HYPOPHYSEAL EXTRACT; FINAL REPORT. Am J Dis Child. 1936;52(1):100–113. doi:10.1001/archpedi.1936.04140010109010
Browse and subscribe to JAMA Network podcasts!
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: