Bulloch and Sequeira in 19051 established the relationship between tumor of the adrenal cortex and pseudohermaphroditism. As early as 1756, however, Cooke described a case of tumor of the adrenal gland in a girl of 7 years of age. She was very obese and had an abnormal growth of hair on the face and pubic region. No attempt was made to point out the part of the gland involved.
In 1910 Apert2 studied a series of cases of tumor of the adrenal cortex in females and concluded that the varying symptomatology depended on the age at which the disease developed. He proposed the following classification:
Type 1. Hyperplasia of the embryonal period. In this type the internal organs are female, but outwardly there are masculine forms, such as undeveloped breasts, a hypospadiac penile-like clitoris and a vulva-like cul-de-sac.
Type 2. Hyperplasia of the fetal period. Here the anomaly
JACOBZINER H, GORFINKEL A. FAMILIAL CONGENITAL ADRENAL SYNDROME. Am J Dis Child. 1936;52(2):308–320. doi:10.1001/archpedi.1936.04140020051006
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