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Progress in Pediatrics
August 1936

CALCINOSIS UNIVERSALIS AND CALCINOSIS CIRCUMSCRIPTA IN INFANCY AND IN CHILDHOOD: THREE CASES OF CALCINOSIS UNIVERSALIS, WITH A REVIEW OF THE LITERATURE

Am J Dis Child. 1936;52(2):368-422. doi:10.1001/archpedi.1936.04140020111011
Abstract

Calcinosis is the term applied to the abnormal deposition of calcium salts in the skin, subcutaneous tissues, muscles and tendons of the body. The first authentic case was reported in association with scleroderma by Weber in 1878, who interpreted the condition as a form of gout. Since then, the syndrome has been the subject of a great deal of discussion and controversy as to the etiology, the pathology and the therapy concerned.

REVIEW OF THE LITERATURE  Calcinosis has been recognized as not being limited to any one disease and has been reported in association with a variety of conditions: scleroderma (Langmead; Tisdall and Erb; Pollitzer; Bayless; Delherm, Morel-Kahn and Coupout; Durham; Bruusgaard), scleroderma with sclerodactylia (Merklen and Vallette; Bertolotti; Olson; Thibierge, Spillman and Weissenbach; von Bernuth, case 2), scleroderma with Raynaud's disease (Hunter; Paisseau, Schaeffer and Scherrer), sclerodactylia alone (Scholefield and Weber), sclerodactylia with Raynaud's disease (Davis), Raynaud's disease alone

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