Sexual precocity, always of interest to the clinician, has become increasingly so of late, because of a more thorough appreciation of the causative factors. Notwithstanding the progress made in this field, there are still cases of precocity associated with lesions of the brain which require further elucidation. Particularly is this true of that type of precocity associated with lesions in the hypothalamic region or with lesions of the brain which are accompanied by chronic increased intracranial pressure and which produce their effects through some disturbance in the hypothalamic-hypophysial mechanism, without producing the ensuing typical lesions in the endocrine glands one generally associates with sexual precocity.
Although some clinicians may doubt that there is any connection between such lesions of the brain or intracranial pressure and their effects on the hypothalamic-infundibular-hypophysial pathway and precocity, others have hinted at the possibilities of such lesions in association with involvement of the pituitary gland.
DORFF GB, SHAPIRO LM. A CLINICOPATHOLOGIC STUDY OF SEXUAL PRECOCITY WITH HYDROCEPHALUS: REPORT OF TWO CASES OCCURRING IN FEMALES, WITH POSTMORTEM OBSERVATIONS IN ONE. Am J Dis Child. 1937;53(2):481–499. doi:10.1001/archpedi.1937.04140090054005
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