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March 1937

THE VARIABLE COURSE OF PERTUSSIS: DOES HAEMOPHILUS PERTUSSIS UNDENATURED BACTERIAL ANTIGEN ALTER IT?

Author Affiliations

SAN FRANCISCO
From the Department of Pediatrics and the George Williams Hooper Foundation for Medical Research, University of California Medical School.

Am J Dis Child. 1937;53(3):720-738. doi:10.1001/archpedi.1937.04140100050003
Abstract

The appearance of reports, in general favorable, on the therapeutic value of Haemophilus pertussis undenatured bacterial antigen (Krueger1) stimulated in us a desire to observe carefully a small number of treated patients, together with suitable control children. The duration of pertussis may vary naturally tenfold. We have seen cases in which the duration was eight days (verified by positive cough plates) and cases in which it was more than eighty days. The frequency of the paroxysms is dependent on innumerable variables, many of which are not understood. It is of course reasonable to suppose that different persons vary tremendously in specific resistance (immunity) and in nonspecific resistance. Frawley2 expressed the belief that the allergic child is more likely to have severe attacks. In regard to age, adults in general have mild attacks, often no doubt because of a clinical or subclinical previous attack which has left a partial

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