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April 1937

A Suggestion for an Experimental Trial of Alum-Treated Formalized Virus in the Active Local and General Immunization Against Poliomyelitis.

Am J Dis Child. 1937;53(4):1171. doi:10.1001/archpedi.1937.04140110241021

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Peskind gives the following résumé:

"Bearing in mind the great enhancement of the immunizing power of diphtheria toxin or toxoid through precipitation with alum, the writer suggests the experimental trial of alum-treated formalized virus as an immunizing agent against poliomyelitis both for local as well as systemic immunization.

"Similarities in the antigenic behaviour of virus and germ antigens would encourage us to expect a similar effect from alum-treated virus as one gets from alum-treated diphtheria toxoid."

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