In 1866, Laurence and Moon first pointed out a syndrome known in later literature (1930) as the Laurence-Moon-Biedl syndrome, the prominent clinical manifestations of which are adiposogenital dystrophia (Fröhlich's syndrome), atypical retinitis pigmentosa, often without the concomitant hyperpigmentation, mental deficiency, familial incidence and skeletal abnormalities, the most frequent of which are polydactylism, usually asymmetrical and postaxial (e. g., toward the little finger or toe), syndactylism and deformity of the skull. Since that time a total of eighty-seven cases have been presented in the literature of the world. In no case, however, was it reported that there was more than one extra digit on a single extremity, although numerous records can be found of a single extra digit on more than one extremity. Males seem to be more often affected than females, but definitely more cases have been reported among the English and the Germans than among other peoples.
LEVINGSTON AG. LAURENCE-MOON-BIEDL SYNDROME. Am J Dis Child. 1937;53(6):1534–1539. doi:10.1001/archpedi.1937.04140130112013
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