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August 1937

STUDIES WITH B C G: IV. THE FOCAL AND THE GENERAL TISSUE RESPONSE AND THE HUMORAL RESPONSE; THE INTRADERMAL ROUTE

Author Affiliations

CHICAGO
From the Tice Laboratories, a detail of the Municipal Tuberculosis Sanitarium (Dr. Frederick Tice, president), the University of Illinois Department of Bacteriology and Public Health (Dr. Lloyd Arnold, director) and the Research Division of the Department of Health of the State of Illinois (Dr. Lloyd Arnold, director).

Am J Dis Child. 1937;54(2):296-321. doi:10.1001/archpedi.1937.01980020090008
Abstract

According to Besredka,1 the organs have receptive cells for certain bacteria, and irrespective of the route of entry of these organisms they become localized in the receptive cells (reticulo-endothelial system) of the specific organs. Coulaud,2 after injection of virulent and avirulent tubercle bacilli subcutaneously, was able to demonstrate tubercles in the lung, as was Makada.3 He concluded that the primary tuberculous complex in the lungs is not necessarily a result of bacterial inhalation but may be due to entry of bacteria through the skin, mucous membranes or intestine (a view held by Calmette and the entire French school).

With the widespread employment of BCG for vacination against tuberculosis, it was soon discovered that when the oral method of administration was used only a small percentage of the persons vaccinated reacted to old tuberculin (from 4 to 10 per cen—Calmette and his co-workers,4 Weill-Hallé5 and others).

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