Three years ago one of us1 reported on clinical and experimental investigations on two children with hemophilia and summarized the current ideas as to the cause of the abnormally prolonged coagulation time in that disease. Also, some experiments were reported regarding the existence of a substance promoting coagulation which should be present in normal plasma and serum and almost absent from the plasma and serum of patients with hemophilia. These experiments were based on the finding of Govaerts and Gratia,2 which was confirmed and amplified, that normal plasma and serum when totally free from the coagulation ferment are able to accelerate coagulation, even in small concentration. Ultrafiltrates of normal plasma or serum do not have this influence. The substance which might be held responsible for the coagulation-promoting influence has been examined more closely. This article contains the results of the investigation and also those of the first clinical
BENDIEN WM, VAN CREVELD S. INVESTIGATIONS ON HEMOPHILIA. Am J Dis Child. 1937;54(4):713–725. doi:10.1001/archpedi.1937.01980040017002
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