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Case Reports
November 1937

SICKLE CELL ANEMIA: CHANGES IN THE VESSELS AND IN THE BONES

Author Affiliations

MAPLEWOOD, N. J.

Am J Dis Child. 1937;54(5):1045-1051. doi:10.1001/archpedi.1937.01980050075009
Abstract

The purpose of this report is to record in the literature by means of visual impressions two further diagnostic features in the syndrome of sickle cell anemia, which were brought out in two cases that I have observed. These are, first, the so-called hair on end appearance in roentgenograms taken of the skulls of patients with long-standing involvement and, secondly, widespread vascular changes.

Roentgenograms showing similar changes have been published in roentgenologic journals (Rose,1 Grinnan,2 Vogt and Diamond,3 Le Wald4), but so far only verbal descriptions have been given in clinical journals, except by Moore.5 The vascular changes have not previously been described, as far as I have been able to discover.

The roentgenograms of the skulls of my patients showed an increase in the thickness of the calvarium in all areas. There was a loss of continuity of the outer table of the skull.

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