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January 1938


Am J Dis Child. 1938;55(1):12-26. doi:10.1001/archpedi.1938.01980070021002

In 1930 Szent-Györgyi1 demonstrated conclusively that the hexuronic (cevitamic) acid isolated from the adrenal glands and crystalline vitamin C are identical. This discovery aroused much interest in the relation between vitamin C and the adrenals. Many workers2 agreed that the adrenals of various animals are among the organs of the body richest in this vitamin. It was a logical step, then, to study the rôle of vitamin C in diseases associated with marked pathologic changes in the adrenals.

Prominent among these maladies is diphtheria. It has been known since 1889 that the adrenals suffer in severe diphtheria. Roux and Yersin3 at that time showed that intense congestion of the adrenal glands can be brought about in guinea-pigs by means of experimental diphtheria. Wybaw,4 Oppenheim,5 Moltschanow6 and others studied the pathologic picture of the adrenals in diphtheria, describing hemorrhagic and degenerative lesions. Oppenheim made extensive

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