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Progress in Pediatrics
April 1938

PRIMARY CARCINOMA OF THE LIVER IN CHILDHOODREPORT OF TWO CASES, WITH A CRITICAL REVIEW OF THE LITERATURE

Am J Dis Child. 1938;55(4):807-824. doi:10.1001/archpedi.1938.01980100143011
Abstract

Primary carcinoma of the liver in children is a pathologic entity of unusual occurrence. Although the greatest incidence of this type of tumor is between the ages of 40 and 60 years, the number of children's cases reported in the literature is sufficient to warrant a consideration of primary neoplasm in the differential diagnosis of enlargements of the liver in childhood. Although various authors have collected and tabulated cases of primary carcinoma of the liver in children, there has been no uniformity of opinion concerning the authenticity of many reports. Philipp1 in 1907 reviewed 29 cases and accepted 12 as genuine. Castle2 in 1914 cited 42 cases of children up to 16 years of age. Griffith3 in 1918 reviewed all the previous cases and tabulated 57, including his own. Kilfoy and Terry4 in 1929 collected from the literature 44 cases of children under 16 years of

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