In order that treatment of congenital syphilis may be begun at the earliest possible moment, an accurate method of diagnosis in the first few months of life—the so-called period of doubt—is of great importance. Faber and Black1 have done much to clarify the significance of a positive Wassermann reaction of the blood in this period. According to these authors, the use of a quantitative rather than a qualitative technic for testing the blood of infants of syphilitic mothers offers a means of early differentiation between infants who have been infected with syphilis and those who have not. This idea was set forth by Faber and Black as follows:
Our hypothesis in using the quantitative method was that with an initially positive reaction to a routine Wassermann test in an infant at or near the time of birth successive quantitative tests might reveal a progressive decline in titer to zero
CHRISTIE AU. DIAGNOSIS OF SYPHILIS IN NEW-BORN INFANTS: USE OF QUANTITATIVE WASSERMANN TESTS. Am J Dis Child. 1938;55(5):979–989. doi:10.1001/archpedi.1938.01980110085006
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