In 1922 Léri and Joanny1 first described a type of pathologic change of the bone for which they proposed the term melorheostosis, or flowing hyperostosis of a limb. The condition, which can be identified roentgenographically, is characterized by a dense cortical hyperostosis causing an enlargement of the affected part and extending in a linear streak along the bones of an extremity into some of the tarsal or carpal bones. In the cases reported, with one exception, the changes were confined to a single extremity, either upper or lower; this localization suggested to Putti2 the name osteosis eburnisans monomelica.
There is no unanimity of opinion as regards the etiology of the condition. Kraft3 summarized four theories: It has been ascribed to (1) a vasomotor neurosis in which the flow of blood to the affected part is altered, (2) an infectious process, (3) a constitutional endocrine disturbance and (4)
GILLESPIE JB, SIEGLING JA. MELORHEOSTOSIS LÉRI. Am J Dis Child. 1938;55(6):1273–1279. doi:10.1001/archpedi.1938.01980120135013
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