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Case Reports
July 1938


Author Affiliations

From the Otho S. A. Sprague Memorial Institute Laboratory of the Children's Memorial Hospital.

Am J Dis Child. 1938;56(1):100-102. doi:10.1001/archpedi.1938.01980130109008

A 13 month old girl was brought to our attention because her urine was reported to contain 2.5 per cent sugar. It was found that although 1 drop of the urine reduced Haines's solution it did not ferment dextrose, and addition of sodium hydroxide produced a black precipitate. The condition was recognized as alkaptonuria, and the patient was admitted to the Children's Memorial Hospital for further study.

This infant was born at full term with normal delivery. The parents were American; they were in good health and were not related. This was the first child, a miscarriage following a fall having terminated the only other pregnancy. The child was breast fed for five months, later receiving cow's milk and evaporated milk. Except for an injury to the head at the age of 9 months and an attack of diarrhea at 4 months, the child had always been well and the