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September 1938

HUMAN PASSIVE TRANSFER ANTIBODY: III. SERIAL TITRATIONS ON TREATED AND UNTREATED PATIENTS WITH HAY FEVER

Author Affiliations

NEW YORK
From the New York Hospital and the Department of Pediatrics, Cornell University Medical College.

Am J Dis Child. 1938;56(3):550-560. doi:10.1001/archpedi.1938.01980150070005
Abstract

Because of its relative frequency and clearly defined seasonal incidence, hay fever has been studied by immunologic methods more often than other allergic disorders which manifest sporadic symptoms. Nevertheless, there are available only limited and contradictory data concerning normal fluctuations and the effect of treatment on the passive transfer antibody titer.

A technic for titration of passive transfer antibody by neutralization, which we previously reported,1 appeared to offer another and perhaps more exact method of approach.

The purpose of this investigation was to determine by serial titrations the fluctuations of passive transfer antibody titer in treated and untreated patients with hay fever. The relation of the titer to the amount of previous treatment and the intensity of clinical symptoms was also recorded.

METHOD AND SUBJECTS  Titration.—The method of titration was described in detail in a previous report.1 It is briefly as follows: 1. A series of mixtures of

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