Because of its relative frequency and clearly defined seasonal incidence, hay fever has been studied by immunologic methods more often than other allergic disorders which manifest sporadic symptoms. Nevertheless, there are available only limited and contradictory data concerning normal fluctuations and the effect of treatment on the passive transfer antibody titer.
A technic for titration of passive transfer antibody by neutralization, which we previously reported,1 appeared to offer another and perhaps more exact method of approach.
The purpose of this investigation was to determine by serial titrations the fluctuations of passive transfer antibody titer in treated and untreated patients with hay fever. The relation of the titer to the amount of previous treatment and the intensity of clinical symptoms was also recorded.
METHOD AND SUBJECTS
Titration.—The method of titration was described in detail in a previous report.1 It is briefly as follows: 1. A series of mixtures of
SCHMIDT WM, LIPPARD VW. HUMAN PASSIVE TRANSFER ANTIBODY: III. SERIAL TITRATIONS ON TREATED AND UNTREATED PATIENTS WITH HAY FEVER. Am J Dis Child. 1938;56(3):550–560. doi:10.1001/archpedi.1938.01980150070005
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