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October 1938

Vaccinazione antitubercolare (vaccinazione coll' anatubercolina Petragnani). By Prof.

Am J Dis Child. 1938;56(4):948. doi:10.1001/archpedi.1938.01980160228018

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This monograph is based on the work of Professor Salvioli with 100 children whom he vaccinated against tuberculosis with the anatuberculin of Petragnani. Most of the work was done on the children of the Foundling Hospital of Siena. He gives a large number of references to the literature. His six years' use of the vaccine prompted him to describe his experience so that it might be available to other physicians.

Professor Salvioli describes the vaccine as a preparation of tubercle bacilli killed with a 1 per cent solution of formaldehyde. The opalescent liquid containing the killed bacilli is used in the vaccination of the children. According to the author, the vaccine possesses all the antigenic characteristics of the live bacilli; it is capable of initiating an allergic state and of maintaining the vaccinal stimulus in the body for months.

The author notes a slowing up of the gain in weight

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