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November 1938

TETANY SYNDROME IN NEWBORN INFANTS: REMOTE DEPOSIT OF CALCIUM SALTS FOLLOWING INJECTION OF CALCIUM GLUCONATE

Am J Dis Child. 1938;56(5):1046-1054. doi:10.1001/archpedi.1938.01980170092012
Abstract

The local precipitation of calcium salts following intramuscular injection of calcium gluconate during treatment of tetany in newborn infants has been reported several times. So far I have seen no paper which mentions the occurrence of abnormal deposits within the body at a place remote from the original site of injection. Because of the rather frightening possibilities that such an eventuality affords, it is my purpose here to report 2 cases in which this phenomenon was observed.

The 2 papers that have come to my attention to date which record in detail the local deposit of calcium salts after injection of calcium gluconate are those of von Hofe and Jennings1 and Tumpeer and Denenholz.2 The former authors reported that calcium gluconate was introduced into both thighs and into the left infrascapular region. Calcium precipitation occurred in all three areas, and in the thighs sloughs developed, from which a

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