Leukemia of all types is characterized by hyperplasia of the tissues which produce the white cells, usually accompanied by the escape of immature forms of cell into the circulating blood. Various types of leukemia have been identified, according to the special type of tissue which is predominantly involved and the type of immature cell in the circulating blood. Thus, there are the so-called myelocytic form, the lymphocytic form and the monocytic form. Other forms have been described, which are not so well established, for example, eosinophilic and basophilic leukemia. With chronic leukemia the recognition of the type is usually easy, but with the acute form the predominant cells are apt to be very immature—and the more immature they are the more difficult the identification of the type becomes. The extremely immature cells resemble each other closely and lack the characteristics of the mature cell by which the type can be
WINSTEAD JA, SMITH CT, WATSON AC. LEUKEMIA OF UNDETERMINED TYPE SUGGESTING MIXED LEUKEMIA. Am J Dis Child. 1938;56(5):1091–1096. doi:10.1001/archpedi.1938.01980170137018
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