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Progress in Pediatrics
November 1938

ADRENAL NEUROBLASTOMA: REPORT OF A CASE AND REVIEW OF THE LITERATURE

Author Affiliations

PHILADELPHIA
From the Department of Pediatrics of Hahnemann Medical College and St. Luke's and Children's Hospitals.

Am J Dis Child. 1938;56(5):1097-1112. doi:10.1001/archpedi.1938.01980170143019
Abstract

Adrenal neuroblastomas occur almost entirely in infants and in children. They constitute an entity the clinical manifestations of which are usually pronounced. Since the number of reported cases in the literature is about 275, the tumors are still to be classed as a medical rarity. Under these conditions it is likely that in many of the cases the diagnosis is first made late in the illness, when metastases are pronounced, or post mortem. Although it must be admitted that treatment up to this time has proved almost entirely ineffective, early recognition should still be a desideratum. Consequently, we feel warranted in reporting an additional case of adrenal neuroblastoma, with a review of the literature.

Virchow1 is generally credited as being the first to recognize the nature of these adrenal tumors in children. Before his work they were not considered to be of nervous origin but were thought to be

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