For about twenty-five years, ever since the earliest attempts to prevent whooping cough by the use of specific vaccines, there have been conflicting reports1 as to their value. In efforts to make the vaccine more effective, changes were made in the method of preparation2 and in the dose.3 The trend has been toward the use of increasingly larger doses of vaccines prepared from virulent or phase I strains.2b The dose has been increased since 1912 from less than a billion bacilli4 to 80 and 100 billion bacilli1c and more.5 As for the method of preparation, Sauer has placed a great deal of emphasis on the necessity of employing recently isolated strains in preference to stock strains, even though their antigenicity has been maintained under suitable cultural conditions.6 In addition, some investigators7 have emphasized the immunizing value of toxic substances in cultures
SIEGEL M. ACTIVE IMMUNIZATION AGAINST WHOOPING COUGH WITH VARIOUS SPECIFIC VACCINES. Am J Dis Child. 1938;56(6):1294–1303. doi:10.1001/archpedi.1938.01980180108009
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